- October 2, 1950 (The first ever Peanuts comic strip. Charlie Brown, Patty and Shermy appear. Patty would not be named until the end of the month and Shermy would not be named until December 18, 1950. The gag in this strip is recycled from the Li'l Folks strip from May 29, 1949. This strip is adapted in Happiness Is a Warm Blanket, Charlie Brown)
- October 3, 1950 (Patty, having her first speaking role, is reciting the traditional nursery rhyme "What Are Little Boys Made Of?" Schulz had previously referenced the rhyme in the Li'l Folks comic strip from October 17, 1948. This is also the first time Shermy is absent)
- October 4, 1950 (The first appearance of Snoopy, the first wordless comic and the first time Charlie Brown is absent)
- October 5, 1950 (This is the first time two characters speak in a full sentence)
- October 6, 1950 (Patty’s 5th appearance in a row)
- October 7, 1950 (The first time Charlie Brown speaks and the first time Patty is absent)
- October 9, 1950 (The first time Shermy shows any affection towards Patty)
- October 10, 1950 (The first interaction between Charlie Brown and Snoopy)
- October 11, 1950
- October 12, 1950
- October 13, 1950
- October 14, 1950
- October 16, 1950 (This gag is recycled from the Li'l Folks strip from July 10, 1949)
- October 17, 1950
- October 18, 1950 (The first strip to feature all four of the original Peanuts characters.)
- October 19, 1950
- October 20, 1950
- October 21, 1950
- October 23, 1950
- October 24, 1950
- October 25, 1950
- October 26, 1950 (Patty is named)
- October 27, 1950 (The first references to baseball and basketball)
- October 28, 1950
- October 30, 1950 (This strip suggests Charlie Brown's birthday is on October 30. However, that would not become an annual feature of Peanuts. His age is not revealed in this strip. He is 4-years-old according to the strip from November 3, 1950)
- October 31, 1950
| ← Li'l Folks, January 1950 | November 1950 → |